Splenda is safer than Sweet n’Low. Itis made FROM sugar, does not adversely affect insulin levels, and does not rot your teeth. If you are a diabetic, or you use a lot of sugar in coffee, tea, on your grapefruit, when making gefilte fish,etc., splenda is less problematic than sugar. Yes, it is 16 calories per teaspoon, but how many of us measure ONLY a teaspoon in our coffee? Stevia is a also a good substitute, from what I hear.
The key is moderation, as in all things. Even WATER drunk to excess can cause poisoning.